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49ers ruled out Nick Bosa (knee/calf) for Week 5 against the Seahawks.

09 October 2026

The 49ers will be without Bosa, FB Kyle Juszczyk (knee), DL James Thompson Jr. (ankle) and S Marques Sigle (ankle) for this divisional showdown, making life a little easier on their opponent.

Trey Lance (groin) is doubtful for Los Angeles’ Week 5 game against the Broncos.

09 October 2026

The rarely-seen doubtful tag. Only the Chargers could discover a way for their backup quarterback to get it. DJ Uiagalelei could backup Justin Herbert this week.

Trevor Penning (concussion) won’t play in Los Angeles’ Week 5 game against the Broncos.

09 October 2026

We’re assuming the Chargers are going to sign some offensive linemen to the 53-man roster, but as things currently stand it looks like four rookies will start next to Cole Strange. And we don’t even know which four, if you really want to see how deep this despair goes.

Jeremiyah Love (ankle) is not on Arizona’s final Week 5 injury report.

09 October 2026

Cardinals coach Mike LaFleur said ""It’s a maintenance thing with ankles, you guys see the way he cuts...I don’t know what he’s totally feeling, only he knows...but he’s doing good.” Great, not cryptic at all, Mike. Love is a reasonable low-end RB2 if his ankles decide he wants to play his full allotment of the 50/50 split against the Lions in Week 5.

Seahawks RB George Holani (ribs/knee) is questionable to play in Week 5 against the 49ers.

09 October 2026

Holani was nursing a ribs injury on Wednesday and Thursday, but he is now listed with a knee injury as well. This is concerning. He clearly picked up a new injury during the practice week. Velus Jones is the current RB3. Jones is not viable as a FLEX starter if Holani sits, but Emanuel Wilson should take on an RB2-worthy workload regardless.

Cardinals DT Walter Nolen (calf) is questionable for Arizona’s Week 5 game against the Lions.

09 October 2026

Nolen was limited in back-to-back practices after popping up with the calf listing on Thursday. He’s played 319 snaps in 21 career opportunities so far.

Seahawks DT Leonard Williams (ankle)is not on the final injury report and will play in Week 5 against the 49ers.

09 October 2026

The Seahawks will have their stud interior defender on hand against the division-rival 49ers. They will be without backup CB Julian Neal (hamstring), who suffered an injury in practice.

Chris Bell (knee) is not on Miami’s final Week 5 injury report.

09 October 2026

He’ll be a FLEX dart throw against the Bengals. Bell continues to get listed with his knee injury as the Dolphins bring him along slowly, but he seems wheels up for Sundays as things currently stand.

Ladd McConkey (foot) is questionable for Los Angeles’ Week 5 game against the Broncos.

09 October 2026

McConkey did not practice all week — though they might tack something on in the non-media period on Friday to make it look better — and is clearly just trying to gut it out at this point. He’ll likely be on a snap count if he does play. But Denver’s cornerback room is severely banged up, so McConkey likely remains in low-end WR2 range this week.

Jacory Croskey-Merritt (groin) is not on the final injury report for Week 5 against the Giants.

09 October 2026

Croskey-Merritt logged two limited sessions to begin the week before upgrading to full on Friday. He should be good to go for this normal weekly role. Unfortunately, his workloads have varied, so he is more of an upside FLEX starter than he is an RB2. That said, Jayden Daniels (elbow) is returning this week, which should give the offense an efficiency boost.

Quentin Johnston (chest) won’t play in Los Angeles’ Week 5 game against the Broncos.

09 October 2026

Johnston got in limited sessions on Thursday and Friday, so it was surprising to see him sent straight to “not playing.” Tre’ Harris figures to step in as Los Angeles’ top outside receiver by snaps this week and is a worthwhile FLEX play, even against a formidable Broncos defense.

Chig Okonkwo (hamstring) is not on the final injury report for Week 5 against the Giants.

09 October 2026

Okonkwo got in a full practice on Friday after consecutive limited sessions. With Stefon Diggs (hamstring) out, Terry McLaurin (hamstring) questionable and Jayden Daniels (elbow) returning, Okonkwo could warrant top-12 positional treatment this week.

Chargers WR Brenen Thompson (quad) will not play in Los Angeles’ Week 5 game against the Broncos.

09 October 2026

He resumed practicing on Wednesday, was downgraded on Thursday, and was ruled out on Friday. There’s a Chargers short story somewhere in there. Thompson hasn’t played since Week 2. Non-dynasty leaguers don’t have to care about this.

Seahawks ruled out Zach Charbonnet (knee) for Week 5 against the 49ers.

09 October 2026

We do not yet know Charbonnet’s Friday participation level, but he remained limited for the first two practices. The Seahawks are smartly bringing him along slowly despite mounting injuries at the position. He should be stashed in 12-team leagues, and could return to a sizable workload when healthy.

Chargers TE Charlie Kolar (forearm) is questionable for Los Angeles’ Week 5 game against the Broncos.

09 October 2026

Kolar has missed a few weeks with a broken forearm after having surgery on it; he appears close to returning. The Chargers are perhaps wondering, looking at their offensive line, if he can play tackle.

Chargers CB Donte Jackson (hamstring) won’t play in Los Angeles’ Week 5 game against the Broncos.

09 October 2026

Assuming Bo Nix is actually willing to throw at his wideouts over the middle this week, Los Angeles’ lack of defensive back depth looks tempting for Nix in a rebound spot.

Will McDonald (calf) is questionable for New York’s Week 5 game against the Browns.

09 October 2026

He popped up on the injury report on Friday, never a great sign. McDonald has a 68.4 PFF pass rush grade on 69 pass rushes and the Jets would lose something on defense without him.

Ja’Marr Chase (concussion) is questionable for Cincinnati’s Week 5 game against the Dolphins.

09 October 2026

He did fully practice today — it feels like this is trending in the right direction, but it’s hard to know without detailed reporting of where he is in the protocol how likely he is to sit. We’re sure there will be many more report on Chase over the next 24-36 hours. He enters the weekend a true question mark.

Commanders rule out Marcus Mariota (knee) for Week 5 against the Giants.

09 October 2026

Mariota’s absence leaves QB3 Athan Kaliakmanis as the team’s top backup behind Jayden Daniels, who is returning from his Week 2 elbow dislocation. Mariota does not need to be rostered in 12-team superflex leagues.

Colbie Young (knee) is questionable for Cincinnati’s Week 5 game against the Dolphins.

09 October 2026

Young went limited-full-limited in three practices this week. The Bengals may be elevating a wideout or two off the practice squad. The Friday downgrade isn’t a great sign for the 2026 fourth-rounder.

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