James Cook (ankle) did not practice Wednesday.

05 November 2025

It’s something of a surprise after Cook appeared fully healthy in Week 9 against the Chiefs. Cook had 114 scoreless yards on 27 rushes against KC, and now has 417 rushing yards over his past three outings. Cook’s DNP could be cautionary ahead of the Bills’ Week 10 matchup with a weak Miami defense. Cook drafters should keep a close eye on his late-week practice status.