James Cook rushed 25 times for 111 yards and two touchdowns in the Bills’ Week 5 win over the Rams, adding seven yards on one reception.

13 October 2026

Cook’s elite rushing line was overshadowed by two fumbles, the second of which was a lost fumble on the team’s first possession of overtime, placing the Rams in position to complete the comeback and steal away the victory. A blocked field goal on what would have been the game-winning kick breathed new life into the Bills, who demonstrated confidence in their lead back by throwing him right back out there on the following possession to eventually win the game. The 26 touches go down as a season high for the veteran back, who found paint for the fourth consecutive game in the thrilling overtime win. Cook remains a top-tier RB1 for fantasy purposes ahead of a Week 6 meeting with the Raiders in Las Vegas.