Colts coach Frank Reich called Parris Campbell's foot injury "significant" and added, "he is going to miss some time."

18 October 2021

Reich didn't have a timetable for Campbell's return and was unable to rule out it being a season-ending injury. It's a tragedy for the third-year receiver who has been unable to stay healthy throughout his time in the NFL. Campbell has 14 games to his name through nearly two and a half seasons. He was coming off his best game of the year, a four-catch outing in Week 5, before injuring his foot versus the Texans. Zach Pascal will step in as the team's No. 3 receiver with Campbell out indefinitely.